Human immunodeficiency virus type 1 shedding pattern in semen correlates with the compartmentalization of viral quasi species between blood and semen

被引：124

作者：

Gupta, P ^{[1
]}

Leroux, C

Patterson, BK

Kingsley, L

Rinaldo, C

Ding, M

Chen, Y

Kulka, K

Buchanan, W

McKeon, B

Montelaro, R

机构：

[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15261 USA

[4] Northwestern Univ, Sch Med, Dept Obstet & Gynecol, Chicago, IL 60611 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2000年 / 182卷 / 01期

关键词：

D O I：

10.1086/315644

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

High levels of human immunodeficiency virus (HIV) type 1 have been detected in semen at all stages of disease. However, it is not clear whether HIV-1 is shed in semen continuously or intermittently. In a prospective longitudinal study viral RNA was measured weekly for 10 weeks in semen and blood of HIV-seropositive subjects, Results showed three different patterns of HIV-1 shedding in semen: none (28%), continuous (28%), and intermittent (44%). In contrast, there was no change in blood plasma virus load during the study period, Phylogenetic analysis of the envelope sequences of HIV-1 RNA in semen and blood revealed distinct virus populations in semen and blood of intermittent shedders but similar virus populations in the semen and blood of continuous shedder. These results indicate for the first time that HIV-1 is shed primarily in an intermittent manner and that shedding patterns of HIV-1 in semen are related to compartmentalization of HIV-1 between semen and blood.

引用

页码：79 / 87

页数：9

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