Asymmetric synthesis of syn-α-substituted β-amino ketones by using sulfinimines and prochiral weinreb amide enolates

被引：55

作者：

Davis, Franklin A. ^{[1
]}

Song, Minsoo ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 12期

关键词：

D O I：

10.1021/ol0708166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

syn-alpha-Substituted beta-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-alpha-substituted beta-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sulfinyl imines).

引用

页码：2413 / 2416

页数：4

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