deLiver'in Regeneration: Injury Response and Development

被引：22

作者：

Curado, Silvia ^{[1
,2
,3
]}

Stainier, Didier Y. R. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, Program Dev Biol, Liver Ctr,Diabet Ctr, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, Program Genet & Human Genet, Liver Ctr,Diabet Ctr, San Francisco, CA 94158 USA

来源：

SEMINARS IN LIVER DISEASE | 2010年 / 30卷 / 03期

关键词：

Hepatopathology; liver; damage; hepatocyte; biliary cell; oval cell; hepatectomy; STEM-CELL NICHE; LIVER-REGENERATION; OVAL CELLS; ALAGILLE-SYNDROME; PROGENITOR CELLS; HUMAN JAGGED1; GROWTH; ZEBRAFISH; GENE; HEPATOCYTES;

D O I：

10.1055/s-0030-1255357

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Liver regeneration has traditionally been investigated in mammalian models. Recent technological developments in mouse genetics have greatly enhanced the resolving power of these studies. In addition, the zebrafish system has emerged as a complementary genetic system to study liver regeneration. One of the most promising attributes of the zebrafish system is its amenability to large-scale screens including genetic and chemical screens. Also, as our understanding of liver development is becoming more detailed, it is important to evaluate the commonalities and differences between organ development and regeneration.

引用

页码：288 / 295

页数：8

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