Synthesis of actiketal, a glutarimide antibiotic

被引：19

作者：

Kiyota, H ^{[1
]}

Shimizu, Y ^{[1
]}

Oritani, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Dept Appl Bioorgan Chem, Div Life Sci,Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

acetals; antibiotics; glutarimides; polyketides;

D O I：

10.1016/S0040-4039(00)00928-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of actiketal (RK-441S), an antibiotic fi-om Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7-dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5887 / 5890

页数：4

共 9 条

[1]

EGAWA Y, 1963, CHEM PHARM BULL, V11, P589

[2] STOFFWECHSELPRODUKTE VON ACTINOMYCETEN .18. ACTIPHENOL [J].