Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

被引：484

作者：

Hancock, Dana B. ^{[1
]}

Eijgelsheim, Mark ^{[2
]}

Wilk, Jemma B. ^{[3
]}

Gharib, Sina A. ^{[4
,5
]}

Loehr, Laura R. ^{[1
,6
]}

Marciante, Kristin D. ^{[4
,7
]}

Franceschini, Nora ^{[6
]}

van Durme, Yannick M. T. A. ^{[8
,9
]}

Chen, Ting-hsu ^{[10
,11
]}

Barr, R. Graham ^{[12
,13
,14
]}

Schabath, Matthew B. ^{[15
]}

Couper, David J. ^{[16
]}

Brusselle, Guy G. ^{[2
,8
,9
]}

Psaty, Bruce M. ^{[4
,7
,17
,18
,19
]}

van Duijn, Cornelia M. ^{[2
]}

Rotter, Jerome I. ^{[20
]}

Uitterlinden, Andre G. ^{[2
]}

Hofman, Albert ^{[2
]}

Punjabi, Naresh M. ^{[22
,23
]}

Rivadeneira, Fernando ^{[2
,21
]}

Morrison, Alanna C. ^{[24
]}

Enright, Paul L. ^{[25
]}

North, Kari E. ^{[6
,26
]}

Heckbert, Susan R. ^{[17
,18
]}

Lumley, Thomas ^{[27
]}

Stricker, Bruno H. C. ^{[2
,21
,28
,29
]}

O'Connor, George T. ^{[10
,11
]}

London, Stephanie J. ^{[1
,30
]}

机构：

[1] NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA

[2] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[3] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[4] Univ Washington, Dept Med, Seattle, WA USA

[5] Univ Washington, Ctr Lung Biol, Seattle, WA 98195 USA

[6] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[7] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[8] Univ Ghent, Dept Resp Med, B-9000 Ghent, Belgium

[9] Ghent Univ Hosp, B-9000 Ghent, Belgium

[10] Boston Univ, Sch Med, Dept Med, Ctr Pulm, Boston, MA 02118 USA

[11] NHLBI, Framingham Heart Study, Framingham, MA USA

[12] Columbia Univ, Coll Phys & Surg, Dept Med, Div Gen Med, New York, NY USA

[13] Columbia Univ, Coll Phys & Surg, Dept Med, Div Pulm Allergy & Crit Care, New York, NY USA

[14] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[15] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[16] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA

[17] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[18] Grp Hlth Cooperat Puget Sound, Ctr Hlth Studies, Seattle, WA 98101 USA

[19] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

[20] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[21] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[22] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[23] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA

[24] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol & Dis Control, Ctr Human Genet, Houston, TX USA

[25] Univ Arizona, Coll Publ Hlth, Tucson, AZ USA

[26] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA

[27] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[28] Netherlands Genom Initiat, Rotterdam, Netherlands

[29] Inspectorate Hlth Care, The Hague, Netherlands

[30] NIEHS, Lab Resp Biol, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 01期

基金：

英国医学研究理事会;

关键词：

LUNG-FUNCTION DECLINE; SEROTONINERGIC RECEPTORS; REFERENCE VALUES; ADAM33; GENE; IDENTIFICATION; HEART; POPULATION; HEDGEHOG; DESIGN; RAGE;

D O I：

10.1038/ng.500

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV1/FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1 (INTS12-GSTCD-NPNT) at or near genome-wide significance (P < 5 x 10(-8)) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.

引用

页码：45 / U61

页数：10

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