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Familial clustering of lone atril fibrillation in patients with saddleback-type ST-segment elevation in right precordial leads
被引:18
作者:
Junttila, M. Juhani
Raatikainen, M. J. Pekka
Perkiomaki, Juha S.
Hong, Kui
Brugada, Ramon
Huikuri, Heikki V.
机构:
[1] Univ Oulu, Dept Internal Med, Div Cardiol, Oulu 90014, Finland
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada
关键词:
atrial fibrillation;
inherited arrhythmias;
electrocardiogram;
D O I:
10.1093/eurheartj/ehl474
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Aims We recently identified a large family with a high prevalence of tone atria[ fibrillation (AF) and saddleback-type ST-segment elevation in leads V1-3, without a history of ventricular arrhythmias or syncope. On the basis of this finding, we studied whether there is a relationship between saddleback ST-elevation and tone AF. Methods and results We examined 168 (mean age 50 +/- 8 years, 130 mates) tone AF patients and 541 (mean age 50 +/- 6 years, 274 mates) healthy subjects. The prevalence of saddleback ST-elevation was higher in the tone AF group than the control group (10 vs. 0.4%, P < 0.001). None had a coved-type ST-elevation in baseline ECG or during drug challenge with ajmaline or flecainide (n = 13), a family history of sudden cardiac death, ventricular tachyarrhythmias, syncope, or any other features diagnostic to the Brugada syndrome. Familial clustering of tone AF (i.e. AF in > 30% of first-degree relatives) was more common among the subjects with saddleback ST-elevation (24 vs. 7%, P=0.03). Conclusion Saddleback-type ST-segment elevation is a relatively common finding among patients with tone AF. The familial clustering of the disorder indicates that genetic factors may be involved in the pathogenesis of the ECG abnormality and tone AF in these patients.
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页码:463 / 468
页数:6
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