Effectiveness of a mass hepatitis A vaccination program in preadolescents

被引：47

作者：

Domínguez, A ^{[1
]}

Salleras, L ^{[1
]}

Carmona, G ^{[1
]}

Batalla, J ^{[1
]}

机构：

[1] Generalitat Catalonia, Gen Dicectorate Publ Hlth, Dept Hlth & Social Secur, Barcelona 08028, Spain

来源：

VACCINE | 2003年 / 21卷 / 7-8期

关键词：

hepatitis A plus B vaccine; effectiveness; hepatitis A incidence;

D O I：

10.1016/S0264-410X(02)00583-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A program of mass hepatitis A + B vaccination in preadolescents in schools was begun in the Catalonia in the last quarter of 1998. This study investigated the impact of the program by comparing the incidence of hepatitis A in vaccinated and unvaccinated cohort. The greatest reduction of the incidence rate of hepatitis A was observed in the 10-14 years age group, from 10.3 per 100,000 persons-year in the period 1996-1998 to 1.8 per 100,000 persons-year in the period 1999-2001. The global incidence decreased from 6.2 to 2.6 per 100,000 persons-year. After analysis of cases occurring in the vaccinated and non vaccinated cohort, the effectiveness of the vaccination program was estimated at 97.0% (95% Cl: 78.6-99.6). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：698 / 701

页数：4

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