The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation

被引：181

作者：

McEwen, B. S. ^{[1
]}

Chattarji, S. ^{[2
]}

Diamond, D. M. ^{[3
,4
,5
,6
]}

Jay, T. M. ^{[7
,8
]}

Reagan, L. P. ^{[9
]}

Svenningsson, P. ^{[10
]}

Fuchs, E. ^{[11
,12
,13
]}

机构：

[1] Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10065 USA

[2] Natl Ctr Biol Sci, Bangalore, Karnataka, India

[3] James A Haley Vet Hosp, Div Med Res, Tampa, FL 33612 USA

[4] Univ S Florida, Ctr Preclin & Clin Res PTSD, Tampa, FL USA

[5] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA

[6] Univ S Florida, Dept Mol Pharmacol & Physiol, Tampa, FL USA

[7] INSERM, U894, Paris, France

[8] Univ Paris 05, Fac Med Paris Descartes, Paris, France

[9] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC USA

[10] Karolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden

[11] German Primate Ctr, Clin Neurobiol Lab, Gottingen, Germany

[12] Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany

[13] Univ Gottingen, DFG Res Ctr Mol Physiol Brain, D-3400 Gottingen, Germany

来源：

MOLECULAR PSYCHIATRY | 2010年 / 15卷 / 03期

关键词：

tianeptine; hippocampus; amygdala; stress; antidepressant; STRESS-INDUCED CHANGES; ANTIDEPRESSANT TIANEPTINE; MAJOR DEPRESSION; ANXIOLYTIC-LIKE; MOOD DISORDERS; SPATIAL MEMORY; SYNAPTIC PLASTICITY; SEXUAL DYSFUNCTION; HIPPOCAMPAL VOLUME; RECEPTOR LIGANDS;

D O I：

10.1038/mp.2009.80

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders. Molecular Psychiatry ( 2010) 15, 237-249; doi: 10.1038/mp.2009.80; published online 25 August 2009

引用

页码：237 / 249

页数：13

共 122 条

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Regulation of hippocampal gene expression is conserved in two species subjected to different stressors and antidepressant treatments [J].