Furosemide and dDAVP for the treatment of pseudohypoaldosteronism type II

被引:5
作者
Erdogan, G
Corapçioglu, D
Erdogan, MF
Hallioglu, J
Uysal, AR
机构
[1] Ankara Univ, Sch Med, Dept Endocrinol & Metab, Ankara, Turkey
[2] Ankara Univ, Sch Med, Dept Anesthesiol & Reanimat, Ankara, Turkey
关键词
pseudohypoaldosteronism; hyperkalemia; hyperchloremia; metabolic acidosis; hypertension; hyporeninemia;
D O I
10.1007/BF03348032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 27-year-old Turkish male presented with fatigue, long lasting hypertension, hyperkalemia, hyperchloremic metabolic acidosis and normal glomerular filtration rate. His brother also showed hyperkalemia with no other features of the disease. Plasma renin levels were low and serum aldosterone levels were inappropriately low-normal to his hyperkalemia. Plasma cortisol levels were normal. Plasma renin aldosterone levels responded appropriately to postural changes, salt restriction and saline infusion. Fludrocortisone was ineffective in his hyperkalemia. The conditions were consistent with Type II pseudohypoaldosteronism (PHA). Furosemide and sodium bicarbonate were effective to control his hyperchloremia, metabolic acidosis and hypertension but partly effective for his hyperkalemia. dDAVP alone did not control the situation and hypertension and metabolic derangement reoccurred. Adding dDAVP to furosemide and sodium bicarbonate successfully controlled hyperkalemia, hyperchloremic acidosis and hypertension. The patient stayed normotensive with normal metabolic and biochemical parameters after 6 months with furosemide and dADVP although sodium bicarbonate had been discontinued after the first month of therapy. dDAVP is a useful adjunct to furosemide and non chloride anions which altogether successfully reverse the metabolic derangement in Type II PHA. (C) 1997, Editrice Kurtis.
引用
收藏
页码:681 / 684
页数:4
相关论文
共 13 条
[1]   HYPERKALEMIA, HYPERTENSION AND SYSTEMIC ACIDOSIS WITHOUT RENAL FAILURE ASSOCIATED WITH A TUBLAR DEFECT IN POTASSIUM EXCRETION [J].
ARNOLD, JE ;
HEALY, JK .
AMERICAN JOURNAL OF MEDICINE, 1969, 47 (03) :461-+
[2]  
BATTLE DC, 1985, CLIN RES, V33, P476
[3]   FAMILIAL HYPERKALEMIA, HYPERTENSION, AND HYPORENINEMIA WITH NORMAL ALDOSTERONE LEVELS - TUBULAR DEFECT IN POTASSIUM HANDLING [J].
BRAUTBAR, N ;
LEVI, J ;
ROSLER, A ;
LEITESDORF, E ;
DJALDETI, M ;
EPSTEIN, M ;
KLEEMAN, CR .
ARCHIVES OF INTERNAL MEDICINE, 1978, 138 (04) :607-610
[4]   EFFECTS OF ANTIDIURETIC-HORMONE ON ELECTROLYTE REABSORPTION AND SECRETION IN DISTAL TUBULES OF RAT-KIDNEY [J].
ELALOUF, JM ;
ROINEL, N ;
DEROUFFIGNAC, C .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1984, 401 (02) :167-173
[5]   INFLUENCE OF ADH ON RENAL POTASSIUM HANDLING - A MICROPUNCTURE AND MICROPERFUSION STUDY [J].
FIELD, MJ ;
STANTON, BA ;
GIEBISCH, GH .
KIDNEY INTERNATIONAL, 1984, 25 (03) :502-511
[6]  
GORDON RD, 1970, AUST ANN MED, V4, P287
[7]  
MELBY JC, 1995, ENDOCRINOLOGY, V2, P1808
[8]   PSEUDOHYPOALDOSTERONISM TYPE-II - PROXIMAL RENAL TUBULAR-ACIDOSIS AND DDAVP-SENSITIVE RENAL HYPERKALEMIA [J].
NAHUM, H ;
PAILLARD, M ;
PRIGENT, A ;
LEVIEL, F ;
BICHARA, M ;
GARDIN, JP ;
IDATTE, JM .
AMERICAN JOURNAL OF NEPHROLOGY, 1986, 6 (04) :253-262
[9]  
PAVER W K, 1964, Med J Aust, V2, P305
[10]   MINERALOCORTICOID RESISTANT RENAL HYPERKALEMIA WITHOUT SALT WASTING (TYPE-II PSEUDO-HYPOALDOSTERONISM) - ROLE OF INCREASED RENAL CHLORIDE REABSORPTION [J].
SCHAMBELAN, M ;
SEBASTIAN, A ;
RECTOR, FC .
KIDNEY INTERNATIONAL, 1981, 19 (05) :716-727