Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK

被引：52

作者：

Lin, HC

Chey, WY

Zhao, XT

机构：

[1] Cedars Sinai Med Ctr, Dept Med, Burns & Allen Res Inst, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[3] Univ Rochester, Med Ctr, Dept Med, Konar Ctr Digest & Liver Dis, Rochester, NY 14642 USA

来源：

PEPTIDES | 2000年 / 21卷 / 10期

基金：

美国国家卫生研究院;

关键词：

gastrointestinal motility; gut peptides;

D O I：

10.1016/S0196-9781(00)00312-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We tested the hypothesis that the release of PYY by fat confined to the proximal small intestine is dependent on CCK. Using a multi-fistulated model, plasma PYY levels were compared in 4 dogs after 60 mM oleate was per-fused into the proximal one-half of the small intestine following i.v. administration of saline or devazepide, a CCK-A antagonist. Plasma PYY increased with fat (P < 0.05), but plasma PYY level was lower following dovazepide at 60 min and 90 min (P < 0.05). We conclude that CCK serves as a foregut signal linking fat in the proximal gut with the release of distal gut PYY. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：1561 / 1563

页数：3

共 13 条

[1] HUMAN DISTRIBUTION AND RELEASE OF A PUTATIVE NEW GUT HORMONE, PEPTIDE-YY [J].