共 30 条
Identification of the ligands of protein interaction domains through a functional approach
被引:29
作者:

Caratu, Ginevral
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

Allegra, Danilo
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

Bimonte, Marida
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

Schiattarella, Gabriele Giacomo
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

D'Ambrosio, Chiara
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

Scaloni, Andrea
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

Napolitano, Maria
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

论文数: 引用数:
h-index:
机构:

Zambrano, Nicola
论文数: 0 引用数: 0
h-index: 0
机构: Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy
机构:
[1] Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy
[2] Fdn Pascales, Ist Nazl Tumori, I-80131 Naples, Italy
[3] CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy
关键词:
D O I:
10.1074/mcp.M600289-MCP200
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
The identification of protein-protein interaction networks has often given important information about the functions of specific proteins and on the cross-talk among metabolic and regulatory pathways. The availability of entire genome sequences has rendered feasible the systematic screening of collections of proteins, often of unknown function, aimed to find the cognate ligands. Once identified by genetic and/or biochemical approaches, the interaction between two proteins should be validated in the physiologic environment. Herein we describe an experimental strategy to screen collections of protein-protein interaction domains to find and validate candidate interactors. The approach is based on the assumption that the overexpression in cultured cells of protein-protein interaction domains, isolated from the context of the whole protein, could titrate the endogenous ligand and, in turn, exert a dominant negative effect. The identification of the ligand could provide us with a tool to check the relevance of the interaction because the contemporary overexpression of the isolated domain and of its ligand could rescue the dominant negative phenotype. We explored this approach by analyzing the possible dominant negative effects on the cell cycle progression of a collection of phosphotyrosine binding (PTB) domains of human proteins. Of 47 PTB domains, we found that the overexpression of 10 of them significantly interfered with the cell cycle progression of NIH3T3 cells. Four of them were used as baits to identify the cognate interactors. Among these proteins, CARM1, interacting with the PTB domain of Rab-GAP1, and EF1 alpha, interacting with RGS12, were able to rescue the block of the cell cycle induced by the isolated PTB domain of the partner protein, thus confirming in vivo the relevance of the interaction. These results suggest that the described approach can be used for the systematic screening of the ligands of various protein-protein interaction domains also by using different biological assays.
引用
收藏
页码:333 / 345
页数:13
相关论文
共 30 条
[1]
Megalin and cubilin: Multifunctional endocytic receptors
[J].
Christensen, EI
;
Birn, H
.
NATURE REVIEWS MOLECULAR CELL BIOLOGY,
2002, 3 (04)
:258-268A

Christensen, EI
论文数: 0 引用数: 0
h-index: 0
机构:
Aarhus Univ, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ, Dept Cell Biol, DK-8000 Aarhus C, Denmark

Birn, H
论文数: 0 引用数: 0
h-index: 0
机构:
Aarhus Univ, Dept Cell Biol, DK-8000 Aarhus C, Denmark Aarhus Univ, Dept Cell Biol, DK-8000 Aarhus C, Denmark
[2]
Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
[J].
Cuif, MH
;
Possmayer, F
;
Zander, H
;
Bordes, N
;
Jollivet, F
;
Couedel-Courteille, A
;
Janoueix-Lerosey, I
;
Langsley, G
;
Bornens, M
;
Goud, B
.
EMBO JOURNAL,
1999, 18 (07)
:1772-1782

Cuif, MH
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Possmayer, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Zander, H
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Bordes, N
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Jollivet, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Couedel-Courteille, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Janoueix-Lerosey, I
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Langsley, G
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Bornens, M
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France

Goud, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Curie, UMR CNRS 144 & 168, F-75248 Paris 05, France
[3]
Interactome: gateway into systems biology
[J].
Cusick, ME
;
Klitgord, N
;
Vidal, M
;
Hill, DE
.
HUMAN MOLECULAR GENETICS,
2005, 14
:R171-R181

Cusick, ME
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA

Klitgord, N
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA

Vidal, M
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA

Hill, DE
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Ctr Canc Syst Biol, Boston, MA 02115 USA
[4]
Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease
[J].
D'Ambrosio, C
;
Arena, S
;
Fulcoli, G
;
Scheinfeld, MH
;
Zhou, DW
;
D'Adamio, L
;
Scaloni, A
.
MOLECULAR & CELLULAR PROTEOMICS,
2006, 5 (01)
:97-113

D'Ambrosio, C
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

Arena, S
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

Fulcoli, G
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

Scheinfeld, MH
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

Zhou, DW
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

D'Adamio, L
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy

Scaloni, A
论文数: 0 引用数: 0
h-index: 0
机构: CNR, ISPAAM, Proteom & Mass Spectrometry Lab, I-80147 Naples, Italy
[5]
EPS8, A SUBSTRATE FOR THE EPIDERMAL GROWTH-FACTOR RECEPTOR KINASE, ENHANCES EGF-DEPENDENT MITOGENIC SIGNALS
[J].
FAZIOLI, F
;
MINICHIELLO, L
;
MATOSKA, V
;
CASTAGNINO, P
;
MIKI, T
;
WONG, WT
;
DIFIORE, PP
.
EMBO JOURNAL,
1993, 12 (10)
:3799-3808

FAZIOLI, F
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

MINICHIELLO, L
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

MATOSKA, V
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

CASTAGNINO, P
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

MIKI, T
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

WONG, WT
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA

DIFIORE, PP
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA NCI, CELLULAR & MOLEC BIOL LAB, BETHESDA, MD 20892 USA
[6]
A NOVEL GENETIC SYSTEM TO DETECT PROTEIN PROTEIN INTERACTIONS
[J].
FIELDS, S
;
SONG, OK
.
NATURE,
1989, 340 (6230)
:245-246

FIELDS, S
论文数: 0 引用数: 0
h-index: 0

SONG, OK
论文数: 0 引用数: 0
h-index: 0
[7]
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
[J].
Garcia, CK
;
Wilund, K
;
Arca, M
;
Zuliani, G
;
Fellin, R
;
Maioli, M
;
Calandra, S
;
Bertolini, S
;
Cossu, F
;
Grishin, N
;
Barnes, R
;
Cohen, JC
;
Hobbs, HH
.
SCIENCE,
2001, 292 (5520)
:1394-1398

Garcia, CK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Wilund, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Arca, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Zuliani, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Fellin, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Maioli, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Calandra, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Bertolini, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Cossu, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Grishin, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Barnes, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Cohen, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

Hobbs, HH
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA
[8]
Functional organization of the yeast proteome by systematic analysis of protein complexes
[J].
Gavin, AC
;
Bösche, M
;
Krause, R
;
Grandi, P
;
Marzioch, M
;
Bauer, A
;
Schultz, J
;
Rick, JM
;
Michon, AM
;
Cruciat, CM
;
Remor, M
;
Höfert, C
;
Schelder, M
;
Brajenovic, M
;
Ruffner, H
;
Merino, A
;
Klein, K
;
Hudak, M
;
Dickson, D
;
Rudi, T
;
Gnau, V
;
Bauch, A
;
Bastuck, S
;
Huhse, B
;
Leutwein, C
;
Heurtier, MA
;
Copley, RR
;
Edelmann, A
;
Querfurth, E
;
Rybin, V
;
Drewes, G
;
Raida, M
;
Bouwmeester, T
;
Bork, P
;
Seraphin, B
;
Kuster, B
;
Neubauer, G
;
Superti-Furga, G
.
NATURE,
2002, 415 (6868)
:141-147

Gavin, AC
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bösche, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Krause, R
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Grandi, P
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Marzioch, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bauer, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Schultz, J
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rick, JM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Michon, AM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Cruciat, CM
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Remor, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Höfert, C
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Schelder, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Brajenovic, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Ruffner, H
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Merino, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Klein, K
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Hudak, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Dickson, D
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rudi, T
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Gnau, V
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bauch, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bastuck, S
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Huhse, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Leutwein, C
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Heurtier, MA
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Copley, RR
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Edelmann, A
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Querfurth, E
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Rybin, V
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Drewes, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Raida, M
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bouwmeester, T
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Bork, P
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Seraphin, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Kuster, B
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Neubauer, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany

Superti-Furga, G
论文数: 0 引用数: 0
h-index: 0
机构: Cellzome AG, D-69117 Heidelberg, Germany
[9]
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
[J].
Ho, Y
;
Gruhler, A
;
Heilbut, A
;
Bader, GD
;
Moore, L
;
Adams, SL
;
Millar, A
;
Taylor, P
;
Bennett, K
;
Boutilier, K
;
Yang, LY
;
Wolting, C
;
Donaldson, I
;
Schandorff, S
;
Shewnarane, J
;
Vo, M
;
Taggart, J
;
Goudreault, M
;
Muskat, B
;
Alfarano, C
;
Dewar, D
;
Lin, Z
;
Michalickova, K
;
Willems, AR
;
Sassi, H
;
Nielsen, PA
;
Rasmussen, KJ
;
Andersen, JR
;
Johansen, LE
;
Hansen, LH
;
Jespersen, H
;
Podtelejnikov, A
;
Nielsen, E
;
Crawford, J
;
Poulsen, V
;
Sorensen, BD
;
Matthiesen, J
;
Hendrickson, RC
;
Gleeson, F
;
Pawson, T
;
Moran, MF
;
Durocher, D
;
Mann, M
;
Hogue, CWV
;
Figeys, D
;
Tyers, M
.
NATURE,
2002, 415 (6868)
:180-183

Ho, Y
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Gruhler, A
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Heilbut, A
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Bader, GD
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Moore, L
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Adams, SL
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Millar, A
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Taylor, P
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Bennett, K
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Boutilier, K
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Yang, LY
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Wolting, C
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Donaldson, I
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Schandorff, S
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Shewnarane, J
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Vo, M
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Taggart, J
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Goudreault, M
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Muskat, B
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Alfarano, C
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Dewar, D
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Lin, Z
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Michalickova, K
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Willems, AR
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Sassi, H
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Nielsen, PA
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Rasmussen, KJ
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Andersen, JR
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Johansen, LE
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Hansen, LH
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Jespersen, H
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Podtelejnikov, A
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Nielsen, E
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Crawford, J
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Poulsen, V
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Sorensen, BD
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Matthiesen, J
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Hendrickson, RC
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Gleeson, F
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Pawson, T
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Moran, MF
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Durocher, D
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Mann, M
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Hogue, CWV
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Figeys, D
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada

Tyers, M
论文数: 0 引用数: 0
h-index: 0
机构: MDS Proteom, Toronto, ON M9W 7H4, Canada
[10]
Physiological actions of regulators of G-protein signaling (RGS) proteins
[J].
Ishii, M
;
Kurachi, Y
.
LIFE SCIENCES,
2003, 74 (2-3)
:163-171

Ishii, M
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Grad Sch Med, Dept Pharmacol, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Dept Pharmacol, Suita, Osaka 5650871, Japan

Kurachi, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Grad Sch Med, Dept Pharmacol, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Med, Dept Pharmacol, Suita, Osaka 5650871, Japan