A positive association between cardiomyocyte volume and serum malondialdehyde levels

被引:9
作者
Adiga, Indira K. [1 ]
Nair, R. Renuka [1 ]
机构
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Div Cellular & Mol Cardiol, Trivandrum 695011, Kerala, India
关键词
cardiomyocytes; hypertrophy; serum lipid peroxidation;
D O I
10.1016/j.ijcard.2006.01.049
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiac hypertrophy is the first visible sign of cardiac remodeling. Oxidative stress is implicated in the etiopathogenesis of cardiac hypertrophy. In vitro studies have shown that exposure of cardiomyocytes to free radical generators induce cell hypertrophy. However, there are no studies to show that in vivo redox status can influence cardiomyocyte growth. Blood samples were collected from healthy volunteers and serum lipid peroxidation was determined as a measure of oxidative stress. Cardiac myocytes cultured from newborn rat were exposed to serum samples. A significant correlation was observed between serum lipid peroxidation and cardiomyocyte volume, indicating that in vivo oxidative stress can act as an important co-factor in mediating the hypertrophic response. This experimental system also envisages a novel approach to identify patients prone to left ventricular remodeling and identification of Immoral factors mediating the changes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:246 / 248
页数:3
相关论文
共 6 条
  • [1] Do the serum oxidative stress biomarkers provide a reasonable index of the general oxidative stress status?
    Argüelles, S
    García, S
    Maldonado, M
    Machado, A
    Ayala, A
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2004, 1674 (03): : 251 - 259
  • [2] Buege J A, 1978, Methods Enzymol, V52, P302
  • [3] Negative regulators of cardiac hypertrophy
    Hardt, SE
    Sadoshima, J
    [J]. CARDIOVASCULAR RESEARCH, 2004, 63 (03) : 500 - 509
  • [4] NAIR RR, 1989, J TISSUE CULT METHOD, V11, P211
  • [5] Role of oxidative stress in myocardial hypertrophy and failure
    Sawyer, DB
    Siwik, DA
    Xiao, L
    Pimentel, DR
    Singh, K
    Colucci, WS
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (04) : 379 - 388
  • [6] Signals of oxidant-induced cardiomyocyte hypertrophy: Key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
    Tu, VC
    Bahl, JJ
    Chen, QM
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (03) : 1101 - 1110