5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

被引：31

作者：

Angibaud, P

Bourdrez, X

Devine, A

End, DW

Freyne, E

Ligny, Y

Muller, P

Mannens, G

Pilatte, I

Poncelet, V

Skrzat, S

Smets, G

Van Dun, J

Van Remoortere, P

Venet, M

Wouters, W

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev, Dept Med Chem, F-27106 Val De Reuil, France

[2] Johnson & Johnson Pharmaceut Res & Dev, Oncol Drug Discovery, Spring House, PA 19477 USA

[3] Johnson & Johnson Pharmaceut Res & Dev, Oncol Discovery Res, B-2340 Beerse, Belgium

[4] Johnson & Johnson Pharmaceut Res & Dev, Preclin Pharmacokinet, B-2340 Beerse, Belgium

[5] Johnson & Johnson Pharmaceut Res & Dev, Drug Evaluat, B-2340 Beerse, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00180-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The evaluation of structure activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1543 / 1547

页数：5

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