Distribution of P2Y receptor subtypes on haematopoietic cells

被引：106

作者：

Jin, JG

Dasari, VR

Sistare, FD

Kunapuli, SP ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19140 USA

[2] US FDA, Div Res & Testing, Off Testing & Res, Ctr Drug Evaluat & Res, Laurel, MD 20708 USA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1998年 / 123卷 / 05期

关键词：

P2Y receptors; P2Y(1) receptors; P2Y(2) receptors; P2Y(4) receptors; P2Y(6) receptors; haematopoietic cell lines; endothelial cells; peripheral blood leukocytes;

D O I：

10.1038/sj.bjp.0701665

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 RT-PCR-southern hybridization analyses with radiolabelled P2Y receptor cDNAs as probes indicated that the peripheral blood leukocytes and the human umbilical vein endothelial cells express P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors. 2 Of the haematopoietic cell lines tested, promonocytic U937 cells express P2Y(2) and P2Y(6), but not P2Y(1) or P2Y(4); promyelocytic HL-60 cells express the P2Y(1), P2Y(2) and P2Y(6) receptors but not the P2Y(4) receptor; K562 cells express P2Y(1) but not P2Y(2), P2Y(4) or P2Y(6); and Dami cells express P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors. 3 Of the peripheral blood leukocytes tested, polymorphonuclear cells express P2Y(4) and P2Y(6) but not P2Y(1) or P2Y(2) receptors; monocytes express P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors and lymphocytes express P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors. 4 These results suggest a physiological role for different P2Y receptor subtypes in the extracellular nucleotide-mediated stimulation of monocytes, neutrophils, lymphocytes and endothelial cells.

引用

页码：789 / 794

页数：6

共 47 条

[1] PURINOCEPTORS - ARE THERE FAMILIES OF P2X AND P2Y PURINOCEPTORS [J].