Human mitochondrial mRNAs-like members of all families, similar but different

被引：151

作者：

Temperley, Richard J. ^{[1
]}

Wydro, Mateusz ^{[1
]}

Lightowlers, Robert N. ^{[1
]}

Chrzanowska-Lightowlers, Zofia M. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Ageing & Hlth, Sch Med, Mitochondrial Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2010年 / 1797卷 / 6-7期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

Mitochondria; RNA; Poly(A); Processing; Transcript; Translation; Termination; INITIATION SITES; TRANSCRIPTION; DNA; TERMINATION; REPLICATION; MUTATION; GENOME; IDENTIFICATION; EXPRESSION; TURNOVER;

D O I：

10.1016/j.bbabio.2010.02.036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The messenger RNAs containing the thirteen protein coding sequences of the human mitochondrial genome have frequently been regarded as a single functional category, alike in arrangement and hence in mode of expression. The "generic" mitochondrial mRNA is perceived as having (i) an arrangement within the polycistronic unit that permits its liberation following mt-tRNA processing, (ii) no 5' cap structure or introns, (iii) essentially no untranslated regions, and (iv) a poly(A) tail of approximately fifty nucleotides that is required in part to complete the termination codon. Closer inspection reveals that only two molecules fit this pattern. This article examines the extent to which human mitochondrial mRNA species differ from one another. (C) 2010 Elsevier B.V. All rights reserved.

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收藏

页码：1081 / 1085

页数：5

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