The North Cumbria Community Genetics Project

被引:36
作者
Chase, DS [1 ]
Tawn, EJ
Parker, L
Jonas, P
Parker, CO
Burn, J
机构
[1] Westlakes Res Inst, Genet Unit, Moor Row CA24 3JZ, Cumbria, England
[2] Univ Newcastle Upon Tyne, Sir James Spence Inst Child Hlth, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England
[3] Univ Newcastle Upon Tyne, Dept Human Genet, Newcastle Upon Tyne NE2 4AA, Tyne & Wear, England
[4] W Cumberland Hosp, Matern Dept, Whitehaven CA28 3JG, Cumbria, England
关键词
population; gene/environment interaction; genetic and epidemiological research; DNA resource;
D O I
10.1136/jmg.35.5.413
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The aim of the North Cumbria Community Genetics Project is to establish a store of DNA, plasma, and viable cells from a cohort of around 8000 Cumbrian infants. To meet this objective, specimens of umbilical cord blood and tissue will be collected with maternal consent from babies born at the West Cumberland Hospital, Whitehaven over a five year period from January 1996. These samples will be used in a series of genetic and epidemiological studies investigating the interaction between genes, the environment, and health. There is little population movement in West Cumbria and so it will be possible to follow many of the babies throughout their childhood and to investigate the relationship between their genetic constitution and health outcome.
引用
收藏
页码:413 / 416
页数:4
相关论文
共 11 条
[1]  
*CENTR STAT OFF, 1996, SOC TRENDS
[2]   PATERNAL EXPOSURE NOT TO BLAME [J].
DOLL, R ;
EVANS, HJ ;
DARBY, SC .
NATURE, 1994, 367 (6465) :678-680
[3]   The repeatability of self-reported exposure after miscarriage [J].
Farrow, A ;
Farrow, SC ;
Little, R ;
Golding, J .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1996, 25 (04) :797-806
[4]   RESULTS OF CASE-CONTROL STUDY OF LEUKEMIA AND LYMPHOMA AMONG YOUNG-PEOPLE NEAR SELLAFIELD NUCLEAR-PLANT IN WEST CUMBRIA [J].
GARDNER, MJ ;
SNEE, MP ;
HALL, AJ ;
POWELL, CA ;
DOWNES, S ;
TERRELL, JD .
BRITISH MEDICAL JOURNAL, 1990, 300 (6722) :423-429
[5]  
Jones S L, 1996, J Obstet Gynecol Neonatal Nurs, V25, P777, DOI 10.1111/j.1552-6909.1996.tb01494.x
[6]   Ethical issues in international collaborative research on the human genome: The HGP and the HGDP [J].
Knoppers, BM ;
Hirtle, M ;
Lormeau, S .
GENOMICS, 1996, 34 (02) :272-282
[7]   Study of the aetiology of wheezing illness at age 16 in two national British birth cohorts [J].
Lewis, S ;
Butland, B ;
Strachan, D ;
Bynner, J ;
Richards, D ;
Butler, N ;
Britton, J .
THORAX, 1996, 51 (07) :670-676
[8]  
Nuffield Council on Bioethics, 1993, GEN SCREEN ETH ISS
[9]   GEOGRAPHICAL-DISTRIBUTION OF PRECONCEPTIONAL RADIATION-DOSES TO FATHERS EMPLOYED AT THE SELLAFIELD NUCLEAR INSTALLATION, WEST CUMBRIA [J].
PARKER, L ;
CRAFT, AW ;
SMITH, J ;
DICKINSON, H ;
WAKEFORD, R ;
BINKS, K ;
MCELVENNY, D ;
SCOTT, L ;
SLOVAK, A .
BRITISH MEDICAL JOURNAL, 1993, 307 (6910) :966-971
[10]   MUTATION ANALYSIS FOR CYSTIC-FIBROSIS TO DETERMINE CARRIER STATUS IN 167 SPERM DONORS FROM THE NEBRASKA GENETIC SEMEN BANK [J].
TRAYSTMAN, MD ;
SCHULTE, NA ;
MACDONALD, M ;
ANDERSON, JR ;
SANGER, WG .
HUMAN MUTATION, 1994, 4 (04) :271-275