Synchrotron radiation circular-dichroism spectroscopy as a tool for investigating protein structures

被引：70

作者：

Wallace, BA

机构：

[1] Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England

[2] Daresbury Lab, Ctr Prot & Membrane Struct & Dynam, Warrington WA4 4AD, Cheshire, England

来源：

JOURNAL OF SYNCHROTRON RADIATION | 2000年 / 7卷 / 07期

关键词：

circular dichroism spectroscopy; protein secondary structures; membrane proteins; structural genomics;

D O I：

10.1107/S0909049500009262

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

This paper reviews the use of synchrotron radiation circular dichroism (SRCD) spectroscopy for examining protein structures, discussing the differences between conventional circular dichroism and SRCD, as well as examples of what SRCD studies have revealed about protein structures to date. It further discusses the future potential of the technique, including roles in structural genomics, membrane protein structure elucidation, relationships to crystallographic studies, and protein folding and dynamics.

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收藏

页码：289 / 295

页数：7

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