Double high-dose chemotherapy with autologous peripheral stem cell rescue in relapsed Wilms' tumor

被引：5

作者：

Maurer, K

Heitger, A

Schwaighofer, H

Fink, FM

Niederwieser, D

机构：

[1] Univ Innsbruck Hosp, Dept Pediat, A-6020 Innsbruck, Austria

[2] Univ Innsbruck Hosp, Dept Internal Med, Div Clin Immunobiol & Bone Marrow Transplantat, A-6020 Innsbruck, Austria

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 20卷 / 12期

关键词：

double high-dose chemotherapy; Wilms' tumor; relapse;

D O I：

10.1038/sj.bmt.1701030

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We performed double high dose chemotherapy (HDCT) and autologous stem cell rescue (ASCR) on an 8-year-old girl after relapse of Wilms' tumor with unfavorable histology. Relapse occurred while the patient was still on first-line therapy and showed multiple adverse prognostic features, Since depleted hematopoietic reserves restricted further conventional therapy, a double HDCT approach was chosen to achieve maximal dose intensity, Four years after relapse the girl is in second remission and well. Double HDCT with ASCR may represent a feasible approach to rescue extensively pretreated patients with recurrent Wilms' tumor of unfavorable histology.

引用

页码：1111 / 1113

页数：3

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