Structurally and functionally distinct mouse hsp70 family members Mot-1 and Mot-2 proteins are encoded by two alleles

被引：23

作者：

Kaul, SC

Duncan, E

Sugihara, T

Reddel, RR

Mitsui, Y

Wadhwa, R

机构：

[1] Chugai Res Inst Mol Med, Ibaraki, Osaka 30041, Japan

[2] AISTI, Natl Inst Biosci & Human Technol, Tsukuba, Ibaraki 3058566, Japan

[3] Childrens Med Res Inst, Westmead, NSW 2145, Australia

来源：

DNA RESEARCH | 2000年 / 7卷 / 03期

关键词：

Mot-1; Mot-2; alleles;

D O I：

10.1093/dnares/7.3.229

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse mortalin proteins Mot-1 and Mot-2 differ by two amino acids in their carboxy-terminus. These proteins are differentially localized in the cell cytoplasm and have contrasting biological activities. The genetic relationship between Mot-1 and Mot-2 was deciphered by mouse family analyses. Mot-2 and Mot-2 segregated in F-1 and F-2 progeny, providing direct evidence that the two proteins are encoded by two alleles.

引用

页码：229 / 231

页数：3

共 8 条

[1] Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein [J].