Isolation and structures of nostopeptolides A1, A2 and A3 from the cyanobacterium Nostoc sp GSV224

被引：43

作者：

Golakoti, T ^{[1
]}

Yoshida, WY ^{[1
]}

Chaganty, S ^{[1
]}

Moore, RE ^{[1
]}

机构：

[1] Univ Hawaii, Dept Chem, Honolulu, HI 96822 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 46期

基金：

美国国家科学基金会;

关键词：

nostopeptolides; depsipeptides; cyanobacterium;

D O I：

10.1016/S0040-4020(00)00764-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The isolation and total structure determinations of nostopeptolides A1 (1), A2 (2) and A3 (3) are described. These cyclic depsipeptides, which are devoid of cytotoxic, antifungal and inhibition of protease activities, are characteristic constituents of the cryptophycin-producing cyanobacterium Nostoc sp. GSV224. Structure elucidation by NMR analysis was made more challenging by the existence of each nostopeptolide in three conformations. One-dimensional TOCSY experiments proved to be very useful in isolating and identifying the nine amino acid residues and the butyryl group in each compound. The absolute stereochemistries of 1-3 were determined by comparing the amino acids in the acid hydrolyzates directly with authentic standards. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9093 / 9102

页数：10

共 9 条

[1]

[Anonymous], [No title captured], Patent No. [US4946835, 4946835]

[2] TOTAL SYNTHESIS OF CRYPTOPHYCINS - REVISION OF THE STRUCTURES OF CRYPTOPHYCIN-A AND CRYPTOPHYCIN-C [J].