Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

被引：78

作者：

Tuttolomondo, Antonino ^{[1
]}

Di Sciacca, Riccardo ^{[1
]}

Di Raimondo, Domenico ^{[1
]}

Serio, Antonia ^{[1
]}

D'Aguanno, Gisella ^{[1
]}

La Placa, Sergio ^{[1
]}

Pecoraro, Rosaria ^{[1
]}

Arnao, Valentina ^{[2
]}

Marino, Luciana ^{[1
]}

Monaco, Serena ^{[3
,4
]}

Natale, Eraldo ^{[3
,4
]}

Licata, Giuseppe ^{[1
]}

Pinto, Antonio ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90127 Palermo, Italy

[2] Univ Palermo, Dipartimento Neurosci Clin, I-90127 Palermo, Italy

[3] Azienda Osped Civ Palermo, Div Neurol, I-90127 Palermo, Italy

[4] Azienda Osped Civ Palermo, Stroke Unit, I-90127 Palermo, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 215卷 / 1-2期

关键词：

Cerebral infarct; Cerebrovascular accident; Cerebrovascular disease; Inflammation; Risk factors; Stroke; Cytokines; NECROSIS-FACTOR-ALPHA; PROINFLAMMATORY CYTOKINES; CEREBRAL-ISCHEMIA; ATRIAL-FIBRILLATION; ARTERY OCCLUSION; CAROTID-ARTERY; BRAIN-DAMAGE; PATHOGENESIS; EXPRESSION; SEVERITY;

D O I：

10.1016/j.jneuroim.2009.06.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. Materials and methods: We evaluated plasma levels of IL-1 beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. Results: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1 beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1 beta. Conclusions: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：84 / 89

页数：6

共 32 条

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