Identification by differential display of a chicken tolloid-related metalloprotease specifically expressed in the caudal notochord

被引：10

作者：

Liaubet, L ^{[1
]}

Bertrand, N ^{[1
]}

Medevielle, F ^{[1
]}

Pituello, F ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, UMR 5547, Ctr Dev Biol, F-31062 Toulouse 04, France

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 96卷 / 01期

关键词：

tolloid-related metalloprotease; astacin; notochord; floor plate; dorso-ventral patterning; neural tube; spinal cord; somite; chicken embryo; differential display;

D O I：

10.1016/S0925-4773(00)00382-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

While the ventralizing factor Sonic hedgehog is expressed in the entire notochord (Development 121 (1995) 2537) the latter displays distinct ventralizing activities along its rostrocaudal axis. Hence, in HH stage-10 chicken embryo, the caudal notochord exhibits floor plate inducing capacities lost by rostral regions (Development 117 (1993) 205). Therefore, we hypothesize that the caudal notochord produces some cofactors which may contribute to its ventralizing properties. In order to identify such molecules we applied the differential display strategy and isolated a secreted Tolloid-related metalloprotease displaying a regionalized expression in the notochord. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：101 / 105

页数：5

共 14 条

[1] Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid [J].