CTS1: A p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

被引：28

作者：

Conseiller, E ^{[1
]}

Debussche, L ^{[1
]}

Landais, D ^{[1
]}

Venot, C ^{[1
]}

Maratrat, M ^{[1
]}

Sierra, V ^{[1
]}

Tocque, B ^{[1
]}

Bracco, L ^{[1
]}

机构：

[1] Rhone Poulenc Rorer SA, Gene Med Dept, F-94403 Vitry Sur Seine, France

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1998年 / 101卷 / 01期

关键词：

p53; mdm2; apoptosis; cancer; gene therapy;

D O I：

10.1172/JCI1140

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The clinical potential of the p53 tumor suppressor gene is being evaluated currently for gene therapy of cancer. We have built a variant of wild-type p53, chimeric tumor suppressor 1 (CTS1), in which we have replaced the domains that mediate its inactivation. CTS1 presents some very interesting properties: (a) enhanced transcriptional activity; (b) resistance to the inactivation by oncogenic forms of p53; (c) resistance to the inactivation by MDM2; (d) lower sensitivity to E6-induced degradation; (e) ability to suppress cell growth; and (f) faster induction of apoptosis. Thus, CTS1 is an improved tumor suppressor and an alternative for the treatment of wild-type p53-resistant human tumors by gene therapy.

引用

页码：120 / 127

页数：8

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