The role of gender in heart transplantation

被引:91
作者
Prendergast, TW
Furukawa, S
Beyer, AJ
Browne, BJ
Eisen, HJ
Jeevanandam, V
机构
[1] Univ Kansas, Med Ctr, Div Cardiothorac Surg, Kansas City, KS 66160 USA
[2] Temple Univ, Hlth Sci Ctr, Sect Cardiac & Thorac Surg, Philadelphia, PA 19140 USA
关键词
D O I
10.1016/S0003-4975(97)01105-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. The effect of donor and recipient gender on the outcome of heart transplantation (HT) remains uncertain. Methods. One hundred seventy-four patients who underwent HT were divided into four groups according to donor and recipient gender. Group A consisted of 81 men who received male donor hearts, group B of 18 women who received female donor hearts, group C of 21 women who received male donor hearts, and group D of 54 men who received female donor hearts. All patients were treated by the same group of surgeons according to standard HT protocols. Comparisons were made between groups with regard to short-and long-term outcomes. Results. Donor gender and recipient gender did not affect outcomes significantly. Overall, donor-recipient gender mismatching significantly increased the number of rejection episodes and reduced creatinine clearance, survival, and censored survival in the first year after HT (p < 0.05). More specifically, among female recipients, donor-recipient gender mismatching significantly increased the number of rejection episodes and decreased creatinine clearance in the first year after HT (p < 0.05); among male recipients, donor-recipient gender mismatching significantly reduced 1-year survival and censored survival to date after HT (p < 0.05). Conclusions. Donor-recipient gender matching plays a significant role in determining HT outcomes. (C) 1998 by The Society of Thoracic Surgeons.
引用
收藏
页码:88 / 94
页数:7
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