Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants

被引：16

作者：

Janssens, W

Salminen, MO

Laukkanen, T

Heyndrickx, L

Van der Auwera, G

Colebunders, R

McCutchan, FE

Van der Groen, G

机构：

[1] Inst Trop Med, Dept Microbiol, B-2000 Antwerp, Belgium

[2] Univ Ghent VIB, B-9052 Ghent, Belgium

[3] Natl Publ Hlth Inst, Dept Infect Dis Epidemiol, HIV Lab, FIN-00300 Helsinki, Finland

[4] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium

[5] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 12期

关键词：

D O I：

10.1089/088922200415045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic, Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes, We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation'' recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.

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页码：1183 / 1189

页数：7

相关论文

共 15 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2]

[Anonymous], 1998, SIMPLOT WINDOWS VERS

[3] Characterization of subtype A HIV-1 from Africa by full genome sequencing [J].

Carr, JK ;

Laukkanen, T ;

Salminen, MO ;

Albert, J ;

Alaeus, A ;

Kim, B ;

Sanders-Buell, E ;

Birx, DL ;

McCutchan, FE .

AIDS, 1999, 13 (14) :1819-1826

[4]

DERIJK P, 1993, COMPUT APPL BIOSCI, V9, P735

[5] Longstanding presence in Belgians of multiple non-B HIV-1 subtypes [J].

Fransen, K ;

Buve, A ;

Nkengasong, JN ;

Laga, M ;

vanderGroen, G .

LANCET, 1996, 347 (9012) :1403-1403

[6] The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin [J].

Gao, F ;

Robertson, DL ;

Morrison, SG ;

Hui, HX ;

Craig, S ;

Decker, J ;

Fultz, PN ;

Girard, M ;

Shaw, GM ;

Hahn, BH ;

Sharp, PM .

JOURNAL OF VIROLOGY, 1996, 70 (10) :7013-7029

[7] Simplified strategy for detection of recombinant human immunodeficiency virus type 1 group M isolates by gag/env heteroduplex mobility assay [J].

Heyndrickx, L ;

Janssens, W ;

Zekeng, L ;

Musonda, R ;

Anagonou, S ;

Van der Auwera, G ;

Coppens, S ;

Vereecken, K ;

De Witte, K ;

Van Rampelbergh, R ;

Kahindo, M ;

Morison, L ;

McCutchan, FE ;

Carr, JK ;

Albert, J ;

Essex, M ;

Goudsmit, J ;

Asjö, B ;

Salminen, M ;

Buvé, A ;

van der Groen, G .

JOURNAL OF VIROLOGY, 2000, 74 (01) :363-370

[8] Sequence note -: HIV type 1 C2V3 env diversity among Belgian individuals [J].

Heyndrickx, L ;

Janssens, W ;

Coppens, S ;

Vereecken, K ;

Willems, B ;

Fransen, K ;

Colebunders, R ;

Vandenbruaene, M ;

Van der Groen, G .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (14) :1291-1296

[9] Virtually full-length sequences of HIV type 1 subtype J reference strains [J].

Laukkanen, T ;

Albert, J ;

Liitsola, K ;

Green, SD ;

Carr, JK ;

Leitner, T ;

McCutchan, FE ;

Salminen, MO .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (03) :293-297

[10] HIV type 1 genetic variability in the northern part of Cameroon [J].

Mboudjeka, I ;

Zekeng, L ;

Takehisa, J ;

Miura, T ;

Ido, E ;

Yamashita, M ;

Kaptue, L ;

Hayami, M .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (11) :951-956