Diffuse optics for tissue monitoring and tomography

被引：875

作者：

Durduran, T. ^{[1
]}

Choe, R. ^{[2
]}

Baker, W. B. ^{[2
]}

Yodh, A. G. ^{[2
]}

机构：

[1] ICFO Inst Ciencies Foton, Castelldefels 08860, Barcelona, Spain

[2] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

来源：

REPORTS ON PROGRESS IN PHYSICS | 2010年 / 73卷 / 07期

关键词：

NEAR-INFRARED SPECTROSCOPY; CEREBRAL-BLOOD-FLOW; PHOTON-DENSITY WAVES; LASER-DOPPLER MEASUREMENTS; TIME-OF-FLIGHT; POSITRON-EMISSION-TOMOGRAPHY; NEWTONS OPTIMIZATION SCHEME; HETEROGENEOUS TURBID MEDIA; BREAST-CANCER DETECTION; TUMORS IN-VIVO;

D O I：

10.1088/0034-4885/73/7/076701

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

This review describes the diffusion model for light transport in tissues and the medical applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue hemodynamics, wherein quantitative assessment of oxy- and deoxy-hemoglobin concentrations and blood flow are desired. The theoretical basis for near-infrared or diffuse optical spectroscopy is developed, and the basic elements of diffuse optical tomography are outlined. We also discuss diffuse correlation spectroscopy, a technique whereby temporal correlation functions of diffusing light are transported through tissue and are used to measure blood flow. Essential instrumentation is described, and representative brain and breast functional imaging and monitoring results illustrate the workings of these new tissue diagnostics.

引用

页数：43

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