The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates

被引：63

作者：

George, TN

Johnson, KJ

Bates, JN

Segar, JL

机构：

[1] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Med, Dept Anesthesia, Iowa City, IA 52242 USA

来源：

JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(98)70370-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effect of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation was studied in nine newborn infants with resolving pulmonary hypertension. Infants treated with iNO at 40 ppm for 30 minutes had bleeding times that were nearly twofold longer than those obtained 24 hours after iNO was discontinued. iNO had no effect on in vitro platelet aggregation studies.

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收藏

页码：731 / 734

页数：4

相关论文

共 12 条

[1]

ABMAN SH, 1993, PEDIATRICS, V92, P606

[2] EVALUATION OF AN AUTOMATED BLEEDING-TIME DEVICE IN THE NEWBORN [J].

ANDREW, M ;

PAES, B ;

BOWKER, J ;

VEGH, P .

AMERICAN JOURNAL OF HEMATOLOGY, 1990, 35 (04) :275-277

[3] ANTIPLATELET EFFECTS OF ENDOTHELIUM-DERIVED RELAXING FACTOR AND NITRIC-OXIDE DONORS [J].

BASSENGE, E .

EUROPEAN HEART JOURNAL, 1991, 12 :12-15

[4] NITROPRUSSIDE INHIBITION OF PLATELET-FUNCTION IS TRANSIENT AND REVERSIBLE BY CATECHOLAMINE PRINTING [J].

HARRIS, SN ;

RINDER, CS ;

RINDER, HM ;

TRACEY, JB ;

SMITH, BR ;

HINES, R .

ANESTHESIOLOGY, 1995, 83 (06) :1145-1152

[5] BLEEDING-TIME PROLONGATION AND NO INHALATION [J].

HOGMAN, M ;

FROSTELL, C ;

ARNBERG, H ;

HEDENSTIERNA, G .

LANCET, 1993, 341 (8861) :1664-1665

[6]

MELLION BT, 1981, BLOOD, V57, P946

[7] COMPARATIVE PHARMACOLOGY OF ENDOTHELIUM-DERIVED RELAXING FACTOR, NITRIC-OXIDE AND PROSTACYCLIN IN PLATELETS [J].

RADOMSKI, MW ;

PALMER, RMJ ;

MONCADA, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 92 (01) :181-187

[8] Inhaled nitric oxide and persistent pulmonary hypertension of the newborn [J].

Roberts, JD ;

Fineman, JR ;

Morin, FC ;

Shaul, PW ;

Rimar, S ;

Schreiber, MD ;

Polin, RA ;

Zwass, MS ;

Zayek, MM ;

Gross, I ;

Heymann, MA ;

Zapol, WM .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (09) :605-610

[9] Nitric oxide inhalation in infants with respiratory distress syndrome [J].

Skimming, JW ;

Bender, KA ;

Hutchison, AA ;

Drummond, WH .

JOURNAL OF PEDIATRICS, 1997, 130 (02) :225-230

[10]

Stork E, 1997, NEW ENGL J MED, V336, P597