Nitric oxide-mediated cGMP production in the islands of Calleja in the rat

被引：15

作者：

de Vente, J

Hopkins, DA

Markerink-van Ittersum, M

Steinbusch, HWM

机构：

[1] Maastricht Univ, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[2] Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS B3H 4H7, Canada

来源：

BRAIN RESEARCH | 1998年 / 789卷 / 01期

关键词：

islands of Calleja; NOS; cGMP; nitric oxide; diffusion; co-localization;

D O I：

10.1016/S0006-8993(98)00099-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

cGMP-immunostaining in the islands of Calleja (ICj) in slices incubated in vitro partially co-localized with nitric oxide synthase (NOS) inside the ICj. No cGMP-immunostaining was found outside the ICj in unstimulated slices, whereas the NO-donor sodium nitroprusside (SNP) stimulated cGMP in cells and fibers bordering on the ICj. These findings show an ongoing NO synthesis in in vitro slices and suggest a relatively restricted diffusion range for endogenously synthesized NO. (C) 1998 Elsevier Science B.V.

引用

页码：175 / 178

页数：4

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