Modelling Heart Beat Initiation and Propagation using the MML Framework

被引：1

作者：

Chang, David ^{[1
]}

Dokos, Socrates ^{[1
]}

Lovell, Nigel H. ^{[1
]}

机构：

[1] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

来源：

2009 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-20 | 2009年

关键词：

D O I：

10.1109/IEMBS.2009.5333683

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The Modeling Markup Language (MML) framework provides a temporo-spatial level modeling tool, consisting of two representation languages with tools which utilize CellML, a mathematical biological model representational language. The purpose of MML is to encourage reuse, sharing and efficiency. In this study, we utilize MML to investigate the role of the hyperpolarizing activated (i(f)) current of the sinoatrial node (SAN), the natural pacemaker of the heart. The i(f) is believed to play an important role in heart automaticity and pacing rate. By using the MML framework and CellML specification, we construct a range of models to examine the role of i(f) in the SAN as well as aspects of wavefront propagation from the SAN into the atria.

引用

页码：4495 / 4498

页数：4

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