Neuregulin is associated with nerve regeneration in axonal neuropathies

被引：14

作者：

Oka, N ^{[1
]}

Kawasaki, T

Matsui, M

Tachibana, H

Sugita, M

Akiguchi, I

机构：

[1] Hyogo Coll Med, Dept Internal Med 5, Nishinomiya, Hyogo 6638501, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 17期

关键词：

axon; nerve regeneration; neuregulin; neuropathy;

D O I：

10.1097/00001756-200011270-00017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuregulins (NRG), the only trophic factors known to support Schwann cell survival, have a potential for use in treatment of patients with chronic neuropathies. Expression of one NRG isoform, NRG-betaI, was increased in axons in the early phase of axonal degeneration in nerve biopsy specimens from patients with neuropathy. Regenerating nerve fibers contained abundant NRG-betaI in axons, but nerves from patients with chronic axonal neuropathy showed less. NRG-betaI may act as an axonally derived signal having a trophic effect on denervated Schwann cells, facilitating their supportive role in axonal regeneration. NeuroReport 11:3673-3676 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3673 / 3676

页数：4

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