Investigations of azapeptides as mimetics of Leu-enkephalin

被引：31

作者：

Han, H

Yoon, J

Janda, KD

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(97)10198-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Solution syntheses of azapeptide pentamers 2, 3, and 4 were accomplished. The binding affinity of these azapeptides and azatide 1 were examined in the context of monoclonal antibody 3-E7 known to strongly bind the [Leu(5)]enkephalin sequence. (C) 1997 Elsevier Science Ltd. All rights reserved.

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页码：117 / 120

页数：4

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