lncRNA/MicroRNA Interactions in the Vasculature

被引：311

作者：

Ballantyne, M. D. ^{[1
,2
]}

McDonald, R. A. ^{[1
]}

Baker, A. H. ^{[1
]}

机构：

[1] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[2] British Heart Fdn Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2016年 / 99卷 / 05期

关键词：

LONG NONCODING RNAS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; MUSCLE-CELL PROLIFERATION; NEOINTIMA FORMATION; EMERGING ROLES; BALLOON INJURY; ANGIOTENSIN-II; WALL CELLS; MICRORNA; GROWTH;

D O I：

10.1002/cpt.355

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited. The influence of miRNA on lncRNA function, and the converse, is now beginning to emerge. lncRNA may regulate miRNA function by acting as endogenous sponges to regulate gene expression and miRNA have been shown to bind and regulate lncRNA stability. A detailed understanding of the molecular and cellular effects of lncRNA-miRNA-mediated interactions in vascular pathophysiology could pave the way for new diagnostic markers and therapeutic approaches, but first there is a requirement for a more detailed understanding of the impact of such regulatory networks.

引用

页码：494 / 501

页数：8

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