Lack of inhibition of endothelial nitric oxide synthase in the isolated rat aorta by doxorubicin

被引：9

作者：

den Hartog, GJM

Boots, AW

Haenen, GRMM

van der Vijgh, WJF

Bast, A

机构：

[1] Univ Maastricht, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, Netherlands

[2] Univ Hosp Vrije Univ, Dept Med Oncol, NL-1081 HV Amsterdam, Netherlands

来源：

TOXICOLOGY IN VITRO | 2003年 / 17卷 / 02期

关键词：

endothelial nitric oxide synthase; doxoribicin; rat; aortic rings;

D O I：

10.1016/S0887-2333(03)00007-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Besides inducing cardiotoxicity, doxorubicin also affects the vasculature. Recent observations in cultured endothelial cells indicated that the endothelial form of nitric oxide synthase might be inhibited by doxorubicin thereby seriously interfering with vascular function. We have investigated the effect of doxorubicin on the relaxation induced by the muscarinic agonist carbachol in the isolated rat aorta. It was found that doxorubicin at concentrations up to 50 mum does not alter the relaxant response to carbachol. Direct measurement of nitrite, the metabolite of NO., by the Griess assay confirmed our observation that NO. production is not inhibited by doxorubicin. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：165 / 167

页数：3

共 11 条

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