Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

被引：14

作者：

Pajor, L

Matolcsy, A

Vass, JA

Méhes, G

Marton, É

Szabó, F

Iványi, JL

机构：

[1] Univ Pecs, Sch Med, Dept Pathol, H-7643 Pecs, Hungary

[2] Markusovszky Hosp, Dept Haematol, Szombathely, Hungary

来源：

LEUKEMIA RESEARCH | 1998年 / 22卷 / 01期

关键词：

myelodysplastic syndrome; acute lymphoblastic leukemia; immunoglobulin gene rearrangement;

D O I：

10.1016/S0145-2126(97)00131-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：13 / 17

页数：5

共 18 条

[1] Progression of a myelodysplastic syndrome to pre-B acute lymphoblastic leukemia: A case report and cell lineage study [J].