Effect of lead toxicity on coenzyme Q levels in rat tissues

被引：26

作者：

Abdallah, Gamil M. ^{[2
]}

El-Sayed, El-Sayed M. ^{[1
]}

Abo-Salem, Osama M. ^{[1
]}

机构：

[1] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Nasr City, Cairo, Egypt

[2] Al Azhar Univ, Fac Pharm, Dept Biochem, Nasr City, Cairo, Egypt

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 06期

关键词：

Lead; Coenzyme Q; Antioxidants; OXIDATIVE STRESS; EXPOSURE; LIVER; Q(10); HYPERTENSION; NEPHROPATHY; UBIQUINONES; PERFORMANCE; REDUCTION; ACID;

D O I：

10.1016/j.fct.2010.04.006

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q(9) and Q(10) in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type. (C) 2010 Elsevier Ltd. All rights reserved.

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页码：1753 / 1756

页数：4

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