Strategies for discovering drugs from previously unexplored natural products

被引：341

作者：

Harvey, A ^{[1
]}

机构：

[1] Drug Discovery Ltd, Glasgow G1 1XW, Lanark, Scotland

来源：

DRUG DISCOVERY TODAY | 2000年 / 5卷 / 07期

关键词：

D O I：

10.1016/S1359-6446(00)01511-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products are the most consistently successful source of drug leads. Despite this, their use in drug discovery has fallen out of favour. Natural products continue to provide greater structural diversity than standard combinatorial chemistry and so they offer major opportunities for finding novel low molecular weight lead structures that are active against a wide range of assay targets. As less than 10% of the world's biodiversity has been tested for biological activity, many more useful natural lead compounds are awaiting discovery. The challenge is how to access this natural chemical diversity.

引用

页码：294 / 300

页数：7

共 66 条

[1] [Anonymous], 1994, ETHNOBOTANY SEARCH N
[2] NATURAL PRODUCT DRUG DISCOVERY AND DEVELOPMENT - NEW PERSPECTIVES ON INTERNATIONAL COLLABORATION
BAKER, JT
BORRIS, RP
CARTE, B
CORDELL, GA
SOEJARTO, DD
CRAGG, GM
GUPTA, MP
IWU, MM
MADULID, DR
TYLER, VE
[J]. JOURNAL OF NATURAL PRODUCTS, 1995, 58 (09): : 1325 - 1357
[3] Blochl E, 1997, EXTREMOPHILES, V1, P14
[4] Plant terpenoid synthases: Molecular biology and phylogenetic analysis
Bohlmann, J
Meyer-Gauen, G
Croteau, R
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) : 4126 - 4133
[5] Boyd MR, 1996, J ETHNOPHARMACOL, V51, P17, DOI 10.1016/0378-8741(95)01346-6
[6] Biochemistry - Harnessing the biosynthetic code: Combinations, permutations, and mutations
Cane, DE
Walsh, CT
Khosla, C
[J]. SCIENCE, 1998, 282 (5386) : 63 - 68
[7] The marine biosphere: A global resource for biotechnology - Introductory overview
Cowan, DA
[J]. TRENDS IN BIOTECHNOLOGY, 1997, 15 (04) : 129 - 131
[8] Natural products in drug discovery and development
Cragg, GM
Newman, DJ
Snader, KM
[J]. JOURNAL OF NATURAL PRODUCTS, 1997, 60 (01): : 52 - 60
[9] Post-translationally modified neuropeptides from Conus venoms
Craig, AG
Bandyopadhyay, P
Olivera, BM
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (02): : 271 - 275
[10] Davies J, 1999, TRENDS BIOCHEM SCI, V24, pM2, DOI 10.1016/S0962-8924(99)01645-1

← 1 2 3 4 5 6 7 →