Guilty as charged: B-RAF is a human oncogene

被引：654

作者：

Garnett, MJ ^{[1
]}

Marais, R ^{[1
]}

机构：

[1] Inst Canc Res, Canc Res UK Ctr Cell & Mol Biol, Signal Transduct Team, London SW3 6JB, England

来源：

CANCER CELL | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1016/j.ccr.2004.09.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform is mutated at a high frequency in human cancer. Here we review the rapid progress made in our understanding of B-RAF as an oncogene and of its role in cancer.

引用

页码：313 / 319

页数：7

共 45 条

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