Clozapine withdrawal catatonia associated with cholinergic and serotonergic rebound hyperactivity - A case report

被引：39

作者：

Yeh, AWC

Lee, JWY

Cheng, TC

Wen, JK

Chen, WH

机构：

[1] Univ Western Australia, Graylands Hosp, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia

[2] Univ Western Australia, Dept Gen & Adolescent Psychiat, Perth, WA 6009, Australia

[3] China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan

[4] Chang Gung Mem Hosp, Dept Neurol, Kaohsiung, Taiwan

来源：

CLINICAL NEUROPHARMACOLOGY | 2004年 / 27卷 / 05期

关键词：

catatonia; clozapine withdrawal; serotonergic hyperactivity;

D O I：

10.1097/01.wnf.0000145506.99636.1b

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Catatonia as a clozapine withdrawal syndrome has not been well documented. There is only 1 case of excited catatonia described with the diagnosis made according to strict criteria. The authors report a patient who developed a catatonic stuporous state following abrupt discontinuation of clozapine, associated with features of cholinergic and serotonergic hyperactivity. The catatonic state resolved within 1 week with reinstatement of clozapine. It is suggested that serotonergic hyperactivity was involved, contributed by cholinergic rebound, in the pathogenesis of this patient's clozapine withdrawal catatonic syndrome.

引用

页码：216 / 218

页数：3

共 17 条

[1] Clozapine withdrawal emergent dystonias and dyskinesias: A case series [J].