Mechanisms maintaining peripheral tolerance

被引：293

作者：

Mueller, Daniel L. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Ctr Immunol, Minneapolis, MN 55455 USA

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 01期

基金：

美国国家卫生研究院;

关键词：

T-CELL TOLERANCE; DENDRITIC CELLS; CLONAL ANERGY; CROSS-PRESENTATION; IN-VIVO; CYCLE PROGRESSION; TRANSGENIC MICE; SELF-ANTIGENS; REGULATORS BIM; CUTTING EDGE;

D O I：

10.1038/ni.1817

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presentation of self-peptide-MHC complexes in the periphery to potentially autoreactive T cells that have escaped negative selection in the thymus poses an important problem to the immune system. In this review, I discuss data that reveal barriers preventing peripheral T cell recognition of self-peptide-MHC complexes, as well as the physiological mechanisms that ensure the elimination or functional inactivation (anergy) of T cells that do come to recognize self-peptide-MHC and threaten the health of the individual.

引用

页码：21 / 27

页数：7

共 87 条

[1] A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells [J].

Ackerman, Anne L. ;

Giodini, Alessandra ;

Cresswell, Peter .

IMMUNITY, 2006, 25 (04) :607-617

[2] CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells [J].

Adler, AJ ;

Marsh, DW ;

Yochum, GS ;

Guzzo, JL ;

Nigam, A ;

Nelson, WG ;

Pardoll, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1555-1564

[3] Projection of an immunological self shadow within the thymus by the aire protein [J].

Anderson, MS ;

Venanzi, ES ;

Klein, L ;

Chen, ZB ;

Berzins, SP ;

Turley, SJ ;

von Boehmer, H ;

Bronson, R ;

Dierich, A ;

Benoist, C ;

Mathis, D .

SCIENCE, 2002, 298 (5597) :1395-1401

[4] P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues [J].

Austrup, F ;

Vestweber, D ;

Borges, E ;

Lohning, M ;

Brauer, R ;

Herz, U ;

Renz, H ;

Hallmann, R ;

Scheffold, A ;

Radbruch, A ;

Hamann, A .

NATURE, 1997, 385 (6611) :81-83

[5] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[6] Cutting edge: Contributions of apoptosis and anergy to systemic T cell tolerance [J].

Barron, Luke ;

Knoechel, Birgit ;

Lohr, Jens ;

Abbas, Andabul K. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (05) :2762-2766

[7] Maintenance of Peripheral Tolerance through Controlled Tissue Homing of Antigen-Specific T Cells in K14-mOVA Mice [J].

Bianchi, Teresa ;

Pincus, Laura B. ;

Wurbel, Marc-Andre ;

Rich, Benjamin E. ;

Kupper, Thomas S. ;

Fuhlbrigge, Robert C. ;

Boes, Marianne .

JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :4665-4674

[8] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity [J].

Bouillet, P ;

Metcalf, D ;

Huang, DCS ;

Tarlinton, DM ;

Kay, TWH ;

Köntgen, F ;

Adams, JM ;

Strasser, A .

SCIENCE, 1999, 286 (5445) :1735-1738

[9] Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection [J].

Brown, Ian E. ;

Blank, Christian ;

Kline, Justin ;

Kacha, Aalok K. ;

Gajewski, Thomas F. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (07) :4521-4529

[10] Langerhans Cells Are Not Required for the CD8 T Cell Response to Epidermal Self-Antigens [J].

Bursch, Laura S. ;

Rich, Benjamin E. ;

Hogquist, Kristin A. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (08) :4657-4664

← 1 2 3 4 5 6 7 8 9 →