A single brain-derived neurotrophic factor injection modifies hypothalamo-pituitary-adrenocortical axis activity in adult male rats

被引：119

作者：

Givalois, L ^{[1
]}

Naert, G ^{[1
]}

Rage, F ^{[1
]}

Ixart, G ^{[1
]}

Arancibia, S ^{[1
]}

Tapia-Arancibia, L ^{[1
]}

机构：

[1] Univ Montpellier 2, Lab Plast Cerebrale, CNRS, F-34095 Montpellier, France

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2004年 / 27卷 / 03期

关键词：

D O I：

10.1016/j.mcn.2004.07.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immobilization stress induces in adult male rats rapid activation of brain derived neurotrophic factor (BDNF) expression in the hypothalamic paraventricular nucleus (PVN) preceding the increases in corticotropin releasing hormone (CRH) and arginin-vasopressin (AVP) expression. The BDNF mRNA signal belatedly co-localizes with CRH and AVP mRNA signals in the PVN, as determined by in situ hybridization. Intracerebroventricular BDNF injections (5 mug/rat) in non-anesthetized adult male rats induce a gradual increase in the CRH mRNA signal whereas AVP mRNA signal progressively decreases in the parvocellular and magnocellular PVN portions. At the same time, the CRH hypothalamic content decreases while the AVP content increases. These variations are accompanied by increases in ACTH and corticosterone plasma concentrations. These results strongly suggest that BDNF could be a stress-responsive intercellular messenger since when it is exogenously administered acts as an important and early component in the activation and recruitment of hypothalamic CRH and AVP neurons. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：280 / 295

页数：16

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