Indium-mediated reaction of 3-bromo-3,3-difluoropropene and bromodifluoromethylacetylene derivatives with aldehydes

被引：53

作者：

Kirihara, M ^{[1
]}

Takuwa, T ^{[1
]}

Takizawa, S ^{[1
]}

Momose, T ^{[1
]}

Nemoto, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 42期

关键词：

indium and compounds; fluorine and compounds;

D O I：

10.1016/S0040-4020(00)00749-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehydes reacted with 3-bromo-3,3-difluoropropene at the a-position in the presence of indium to afford 1-substituted-2,2-difluorobut-3-en-1-ols. Ketones and other electrophiles are inert under the examined conditions. The reaction of bromodifluoromethyl-acetylene derivatives with an aldehyde in the presence of indium provided difluorohomopropargylic alcohols. These reactions efficiently proceeded in polar solvents (water, DMF) under mild conditions. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8275 / 8280

页数：6

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