Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine

被引：144

作者：

Howden, BP

Slavin, MA

Schwarer, AP

Mijch, AM

机构：

[1] Alfred Hosp, Dept Infect Dis, Melbourne, Vic 3181, Australia

[2] Alfred Hosp, Bone Marrow Programme, Melbourne, Vic 3181, Australia

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2003年 / 22卷 / 02期

关键词：

D O I：

10.1007/s10096-002-0877-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Disseminated Scedosporium prolificans infections are almost uniformly fatal because of their resistance to antifungal agents. Recently, synergy between triazoles and terbinafine has been demonstrated against Scedosporium prolificans in vitro. Reported here is a patient who developed disseminated Scedosporium prolificans infection following bone marrow transplantation and who was successfully treated with a combination of voriconazole and terbinafine in addition to aggressive surgical debridement. Antifungal synergy testing and combination therapy should be considered in cases of disseminated infection with Scedosporium prolificans.

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页码：111 / 113

页数：3

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