The source(s) for new pancreatic beta cells in adult life

被引：7

作者：

Bock, T

机构：

[1] Univ Copenhagen Hosp, Res Lab Stereol & Neurosci, HS Bispebjerg Hosp, DK-2400 Copenhagen, Denmark

[2] HS Rigshosp, Bartholin Inst, Copenhagen, Denmark

来源：

BIOESSAYS | 2004年 / 26卷 / 11期

关键词：

D O I：

10.1002/bies.20143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al.((1)) investigated beta-cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta-cell replication was the only source for new beta cells without contributions from stem cells or other non-beta cells. This underlines the capacity for beta-cell self-renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas. (C) 2004 Wiley Periodicals, Inc.

引用

收藏

页码：1156 / 1159

页数：4

相关论文

共 37 条

[1] Insulin production by human embryonic stem cells [J].

Assady, S ;

Maor, G ;

Amit, M ;

Itskovitz-Eldor, J ;

Skorecki, KL ;

Tzukerman, M .

DIABETES, 2001, 50 (08) :1691-1697

[2] Increased islet volume but unchanged islet number in ob/ob mice [J].

Bock, T ;

Pakkenberg, B ;

Buschard, K .

DIABETES, 2003, 52 (07) :1716-1722

[3] Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors [J].

Bogdani, M ;

Lefebvre, V ;

Buelens, N ;

Bock, T ;

Pipeleers-Marichal, M ;

In't Veld, P ;

Pipeleers, D .

DIABETOLOGIA, 2003, 46 (06) :830-838

[4] In vitro cultivation of human islets from expanded ductal tissue [J].

Bonner-Weir, S ;

Taneja, M ;

Weir, GC ;

Tatarkiewicz, K ;

Song, KH ;

Sharma, A ;

O'Neil, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7999-8004

[5] Pancreatic stem cells [J].

Bonner-Weir, S ;

Sharma, A .

JOURNAL OF PATHOLOGY, 2002, 197 (04) :519-526

[6] A 2ND PATHWAY FOR REGENERATION OF ADULT EXOCRINE AND ENDOCRINE PANCREAS - A POSSIBLE RECAPITULATION OF EMBRYONIC-DEVELOPMENT [J].

BONNERWEIR, S ;

BAXTER, LA ;

SCHUPPIN, GT ;

SMITH, FE .

DIABETES, 1993, 42 (12) :1715-1720

[7] MORPHOLOGICAL EVIDENCE FOR PANCREATIC POLARITY OF BETA-CELL WITHIN ISLETS OF LANGERHANS [J].

BONNERWEIR, S .

DIABETES, 1988, 37 (05) :616-621

[8] Pharmacological treatment of chronic diabetes by stimulating pancreatic β-cell regeneration with systemic co-administration of EGF and gastrin [J].

Brand, SJ ;

Tagerud, S ;

Lambert, P ;

Magill, SG ;

Tatarkiewicz, K ;

Doiron, K ;

Yan, YH .

PHARMACOLOGY & TOXICOLOGY, 2002, 91 (06) :414-420

[9] Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes -: Evidence for role of islet amyloid formation rather than direct action of amyloid [J].

Butler, AE ;

Janson, J ;

Soeller, WC ;

Butler, PC .

DIABETES, 2003, 52 (09) :2304-2314

[10] β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

← 1 2 3 4 →