Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling

被引：37

作者：

Aitken, CJ

Hodge, JM

Nishinaka, Y

Vaughan, T

Yodoi, JJ

Day, CJ

Morrison, NA

Nicholson, GC ^{[1
]}

机构：

[1] Univ Melbourne, Geelong Hosp, Dept Clin & Biomed Sci, Barwon Hlth, Geelong, Vic 3220, Australia

[2] Natl Inst Adv Ind Sci & Technol, Human Stress Signal Res Ctr, Biomed Special Res Unit, Osaka, Japan

[3] Griffith Univ, Sch Hlth Sci, Nathan, Qld 4111, Australia

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 12期

关键词：

osteoclast; thioredoxin binding protein-2; thioredoxin-1; redox; activator protein 1;

D O I：

10.1359/JBMR.040913

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Differential expression of TBP-2 and Trx-1 occurs during osteoclastogenesis. Adenoviral overexpression of TBP-2 in osteoclast precursors inhibits Trx-1 expression, osteoclast formation, and AP-1 binding activity. TBP-2 and Trx-1 are key regulators of osteoclastogenesis.

引用

收藏

页码：2057 / 2064

页数：8

相关论文

共 53 条

[1] Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line [J].

Armstrong, JS ;

Steinauer, KK ;

Hornung, B ;

Irish, JM ;

Lecane, P ;

Birrell, GW ;

Peehl, DM ;

Knox, SJ .

CELL DEATH AND DIFFERENTIATION, 2002, 9 (03) :252-263

[2] Association between oxidative stress and bone mineral density [J].

Basu, S ;

Michaëlsson, K ;

Olofsson, H ;

Johansson, S ;

Melhus, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 288 (01) :275-279

[3] STIMULATION OF OSTEOCLASTIC BONE-RESORPTION BY HYDROGEN-PEROXIDE [J].

BAX, BE ;

ALAM, ASMT ;

BANERJI, B ;

BAX, CMR ;

BEVIS, PJR ;

STEVENS, CR ;

MOONGA, BS ;

BLAKE, DR ;

ZAIDI, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 183 (03) :1153-1158

[4] The free radical theory of aging matures [J].

Beckman, KB ;

Ames, BN .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581

[5] Positional cloning of the combined hyperlipidemia gene Hyplip1 [J].

Bodnar, JS ;

Chatterjee, A ;

Castellani, LW ;

Ross, DA ;

Ohmen, J ;

Cavalcoli, J ;

Wu, CY ;

Dains, KM ;

Catanese, J ;

Chu, M ;

Sheth, SS ;

Charugundla, K ;

Demant, P ;

West, DB ;

de Jong, P ;

Lusis, AJ .

NATURE GENETICS, 2002, 30 (01) :110-116

[6] Osteoclast differentiation and activation [J].

Boyle, WJ ;

Simonet, WS ;

Lacey, DL .

NATURE, 2003, 423 (6937) :337-342

[7] ISOLATION AND CHARACTERIZATION OF A NOVEL CDNA FROM HL-60 CELLS TREATED WITH 1,25-DIHYDROXYVITAMIN D-3 [J].

CHEN, KS ;

DELUCA, HF .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1219 (01) :26-32

[8] Free radicals in the physiological control of cell function [J].

Dröge, W .

PHYSIOLOGICAL REVIEWS, 2002, 82 (01) :47-95

[9] Redox regulation of NF-kappa B activation [J].

Flohe, L ;

Brigelius-Flohe, R ;

Saliou, C ;

Traber, MG ;

Packer, L .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (06) :1115-1126

[10] Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae [J].

Fraser, JHE ;

Helfrich, MH ;

Wallace, HM ;

Ralston, SH .

BONE, 1996, 19 (03) :223-226

← 1 2 3 4 5 6 →