Controlled Release of Naringin in GelMA-Incorporated Rutile Nanorod Films to Regulate Osteogenic Differentiation of Mesenchymal Stem Cells

被引：32

作者：

Shao, Yangjie ^{[1
]}

You, Dongqi ^{[1
]}

Lou, Yiting ^{[1
,2
]}

Li, Jianhua ^{[3
]}

Ying, Binbin ^{[2
]}

Cheng, Kui ^{[4
]}

Weng, Wenjian ^{[4
]}

Wang, Huiming ^{[1
]}

Yu, Mengfei ^{[1
,2
,3
,4
]}

Dong, Lingqing ^{[1
,4
]}

机构：

[1] Zhejiang Univ, Affiliated Stomatol Hosp, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Ningbo Hosp 1, Dept Stomatol, Ningbo 315010, Zhejiang, Peoples R China

[3] Hangzhou Dent Hosp, Hangzhou 310006, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sch Mat Sci & Engn, State Key Lab Silicon Mat, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ACS OMEGA | 2019年 / 4卷 / 21期

基金：

中国国家自然科学基金;

关键词：

GELATIN; HYDROGELS;

D O I：

10.1021/acsomega.9b02751

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Naringin, a Chinese herbal medicine, has been demonstrated to concentration-dependently promote osteogenic differentiation of mesenchymal stem cells (MSCs). However, it remains a challenge to load naringin on coatings for osteogenesis and further control the release kinetics. Here, we demonstrated that the release behavior of naringin on rutile nanorod films could be controlled by either mixing naringin with gelatin methacryloyl (GelMA) before spinning onto the films or soaking the obtained GelMA-incorporated films with the naringin solution to achieve the distinct degradation-type release and diffusion-type release, respectively. We further revealed that the naringin-loaded coatings facilitated adhesion, proliferation and late differentiation, and mineralization of MSCs. Our findings provided a novel strategy to engineer the coatings with controlled release of naringin and emphasized the bioactivity of naringin for the osteogenic differentiation of MSCs.

引用

页码：19350 / 19357

页数：8

共 32 条

[1]

Engineering biocompatible implant surfaces Part I: Materials and surfaces [J].