Synthetic glycopeptides and glycoproteins as tools for biology

被引：185

作者：

Pratt, MR

Bertozzi, CR ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, Ctr Adv Mat, Berkeley, CA 94720 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2005年 / 34卷 / 01期

关键词：

D O I：

10.1039/b400593g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Investigations into the roles of protein glycosylation have revealed functions such as modulating protein structure and localization, cell-cell recognition, and signaling in multicellular systems. However, detailed studies of these events are hampered by the heterogeneous nature of biosynthetic glycoproteins that typically exist in numerous glycoforms. Research into protein glycosylation, therefore, has benefited from homogeneous, structurally-defined glycoproteins obtained by chemical synthesis. This tutorial review focuses on recent applications of homogeneous synthetic glycopeptides and glycoproteins for studies of structure and function. In addition, the future of synthetic glycopeptides and glycoproteins as therapeutics is discussed.

引用

页码：58 / 68

页数：11

共 66 条

[1] Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability [J].