Calcium channels diversify their signaling portfolio

被引:6
作者
Ikeda, Stephen R. [1 ]
Dunlap, Kathleen
机构
[1] NIAAA, Lab Mol Physiol, NIH, Bethesda, MD 20892 USA
[2] Tufts Univ, Dept Neurosci, Boston, MA 02111 USA
关键词
D O I
10.1038/nn0307-269
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sensory neurons express sets of ion channels that contribute to pain transmission. A new study finds that a sensory neuron–specific exon encodes a molecular switch that recruits other signaling pathways to N-type Ca2+ channels.
引用
收藏
页码:269 / 271
页数:4
相关论文
共 15 条
[1]   Cell-specific alternative splicing increases calcium channel current density in the pain pathway [J].
Bell, TJ ;
Thaler, C ;
Castiglioni, AJ ;
Helton, TD ;
Lipscombe, D .
NEURON, 2004, 41 (01) :127-138
[2]   Relief of G-protein inhibition of calcium channels and short-term synaptic facilitation in cultured hippocampal neurons [J].
Brody, DL ;
Yue, DT .
JOURNAL OF NEUROSCIENCE, 2000, 20 (03) :889-898
[3]   Novel form of crosstalk between G protein and tyrosine kinase pathways [J].
DiversePierluissi, M ;
Remmers, AE ;
Neubig, RR ;
Dunlap, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (10) :5417-5421
[4]   Phosphotidylinositol 4,5-bisphosphate signals underlie receptor-specific Gq/11-mediated modulation of N-type Ca2+ channels [J].
Gamper, N ;
Reznikov, V ;
Yamada, Y ;
Yang, J ;
Shapiro, MS .
JOURNAL OF NEUROSCIENCE, 2004, 24 (48) :10980-10992
[5]   Modulation of Ca2+ channels by G-protein beta gamma subunits [J].
Herlitze, S ;
Garcia, DE ;
Mackie, K ;
Hille, B ;
Scheuer, T ;
Catterall, WA .
NATURE, 1996, 380 (6571) :258-262
[6]  
IKEDA SR, 1996, NATURE, V380, P258
[7]   A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Gαq/11 and Gβγ [J].
Kammermeier, PJ ;
Ruiz-Velasco, V ;
Ikeda, SR .
JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5623-5629
[8]   Altered nociceptive response in mice deficient in the α1B subunit of the voltage-dependent calcium channel [J].
Kim, C ;
Jun, K ;
Lee, T ;
Kim, SS ;
McEnery, MW ;
Chin, H ;
Kim, HL ;
Park, JM ;
Kim, DK ;
Jung, SJ ;
Kim, J ;
Shin, HS .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2001, 18 (02) :235-245
[9]   Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Cavα1 [J].
Lipscombe, D ;
Pan, JQ ;
Gray, AC .
MOLECULAR NEUROBIOLOGY, 2002, 26 (01) :21-44
[10]   AMMONIA VOLATILIZATION FROM SOILS [J].
MILLS, HA ;
BARKER, AV ;
MAYNARD, DN .
AGRONOMY JOURNAL, 1974, 66 (03) :355-358