The first stereoselective total synthesis of (6,S)-5,6-dihydro-1(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one

被引：37

作者：

Chandrasekhar, S ^{[1
]}

Narsihmulu, C ^{[1
]}

Sultana, SS ^{[1
]}

Reddy, MS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 50期

关键词：

maruoka asymmetric allylation; Keck asymmetric allylation; ring-closing metathesis;

D O I：

10.1016/j.tetlet.2004.10.059

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iterative asymmetric allylations and ring-closing metathesis have been effectively performed for the first stereoselective total synthesis of (6S)-5,6-dihydro-6-[(2R)-2-liydroxy-6-phenylhexyl]-2H-pyran-2-one, a novel alpha,beta-unsaturated-delta-lactone having antifungal activity, isolated from Rauensara crassifolia. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9299 / 9301

页数：3

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