Rat arteries contain multiple nicotinic acetylcholine receptor α-subunits

被引：32

作者：

Brüggmann, D ^{[1
]}

Lips, KS ^{[1
]}

Pfeil, U ^{[1
]}

Haberberger, RV ^{[1
]}

Kummer, W ^{[1
]}

机构：

[1] Univ Giessen, Inst Anat & Cell Biol, D-35385 Giessen, Germany

来源：

LIFE SCIENCES | 2003年 / 72卷 / 18-19期

关键词：

acetylcholine; cholinergic receptors; immunohistochemistry;

D O I：

10.1016/S0024-3205(03)00067-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the occurrence and distribution of the ligand-binding alpha-subunits of nicotinic acetylcholine receptors in the rat arterial system in situ by means of RT-PCR and immunohistochemistry. Except the alpha9-subunit, all other mammalian non-muscular a-subunits were expressed in the arterial wall - either in endothelial or in smooth muscle cells - suggesting it as a direct target of nicotine and endogenous acetylcholine. The distribution pattern of a-subunits found in smooth muscle cells varied considerably among the individual elastic, muscular and intraparenchymal arteries investigated, suggesting that non-neuronal cholinergic signalling via nicotinic receptors in the vascular wall includes components that are highly specific for individual arteries. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：2095 / 2099

页数：5

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