Hepcidin, a new iron regulatory peptide

被引:269
作者
Nicolas, G
Viatte, L
Bennoun, M
Beaumont, C
Kahn, A
Vaulont, S
机构
[1] Fac Med Cochin, Dept Genet Dev & Pathol Mol, Inst Cochin, F-75014 Paris, France
[2] Inst Cochin, INSERM, Dept Genet Dev & Pathol Mol, CNRS, F-75014 Paris, France
[3] Univ Paris 05, Fac Med Cochin Port Royal, F-75014 Paris, France
[4] Univ Paris 07, INSERM, F-75018 Paris, France
关键词
D O I
10.1006/bcmd.2002.0573
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction. Recently, several lines of evidence have suggested that hepcidin, a peptide mainly produced by the liver, plays a major role in the control of body iron homeostasis. The subject of this paper is to summarize the advances toward the understanding of function and regulation of hepcidin in iron metabolism and to provide new data on the regulation of hepcidin gene expression by erythropoietin, the major regulator of mammalian erythropoiesis. (C) 2002 Elsevier Science (USA).
引用
收藏
页码:327 / 335
页数:9
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